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Journal of Bacteriology, December 2005, p. 8516-8519, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8516-8519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

An {alpha}/ß-Fold C{cjs0807}C Bond Hydrolase Is Involved in a Central Step of Nicotine Catabolism by Arthrobacter nicotinovorans

Paula Sachelaru,1 Emile Schiltz,2 Gabor L. Igloi,3 and Roderich Brandsch1*

Institut für Biochemie und Molekularbiologie,1 Institut für Organische Chemie und Biochemie,2 Institut für Biologie III, Universität Freiburg, Freiburg, Germany3

Received 15 September 2005/ Accepted 22 September 2005

The enzyme catalyzing the hydrolytic cleavage of 2,6-dihydroxypseudooxynicotine to 2,6-dihydroxypyridine and {gamma}-N-methylaminobutyrate was found to be encoded on pAO1 of Arthrobacter nicotinovorans. The new enzyme answers an old question about nicotine catabolism and may be the first C{cjs0807}C bond hydrolase that is involved in the biodegradation of a heterocyclic compound.

* Corresponding author. Mailing address: Institut für Biochemie und Molekularbiologie, Hermann-Herder-Str. 7, 79104 Freiburg, Germany. Phone: 49-761-203-5230. Fax: 49-761-203-5253. E-mail: roderich.brandsch{at}biochemie.uni-freiburg.de.

Journal of Bacteriology, December 2005, p. 8516-8519, Vol. 187, No. 24
0021-9193/05/$08.00+0     doi:10.1128/JB.187.24.8516-8519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tang, H., Wang, S., Ma, L., Meng, X., Deng, Z., Zhang, D., Ma, C., Xu, P. (2008). A Novel Gene, Encoding 6-Hydroxy-3-Succinoylpyridine Hydroxylase, Involved in Nicotine Degradation by Pseudomonas putida Strain S16. Appl. Environ. Microbiol. 74: 1567-1574 [Abstract] [Full Text]  
  • Mihasan, M., Chiribau, C.-B., Friedrich, T., Artenie, V., Brandsch, R. (2007). An NAD(P)H-Nicotine Blue Oxidoreductase Is Part of the Nicotine Regulon and May Protect Arthrobacter nicotinovorans from Oxidative Stress during Nicotine Catabolism. Appl. Environ. Microbiol. 73: 2479-2485 [Abstract] [Full Text]  


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