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Journal of Bacteriology, February 2005, p. 1515-1518, Vol. 187, No. 4
0021-9193/05/$08.00+0     doi:10.1128/JB.187.4.1515-1518.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

SOS-Independent Induction of dinB Transcription by ß-Lactam-Mediated Inhibition of Cell Wall Synthesis in Escherichia coli

Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid,¹ Servicio de Microbiología, Hospital Ramón y Cajal,² Laboratorio de Evolución Microbiana, Centro de Astrobiología (INTA-CSIC), Madrid, Spain³

Received 9 September 2004/ Accepted 15 November 2004

Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the ß-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.

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