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Journal of Bacteriology, March 2005, p. 1845-1848, Vol. 187, No. 5
0021-9193/05/$08.00+0     doi:10.1128/JB.187.5.1845-1848.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

DNA Bridging: a Property Shared among H-NS-Like Proteins

Remus T. Dame,^1* Martijn S. Luijsterburg,^1, Evelyne Krin,² Philippe N. Bertin,³ Rolf Wagner,⁴ and Gijs J. L. Wuite¹

Physics of Complex Systems, Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit, Amsterdam, The Netherlands,¹ Unité de Genetique des Genomes Bacteriens, Institut Pasteur, Paris,² Laboratoire de Dynamique, Evolution et Expression de Génomes de Microorganismes, FRE2326, Université Louis Pasteur/CNRS, Strasbourg, France,³ Institut für Physikalische Biologie, Heinrich-Heine-Universität, Düsseldorf, Germany⁴

Received 14 September 2004/ Accepted 29 November 2004

The nucleoid-associated protein H-NS is thought to play an essential role in the organization of bacterial chromatin in Escherichia coli. Homologues, often with very low sequence identity, are found in most gram-negative bacteria. Microscopic analysis reveals that, despite limited sequence identity, their structural organization results in similar DNA binding properties.

Present address: Swammerdam Institute for Life Sciences, Universiteit van Amsterdam, Amsterdam, The Netherlands.

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