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Journal of Bacteriology, March 2005, p. 1866-1874, Vol. 187, No. 5
0021-9193/05/$08.00+0     doi:10.1128/JB.187.5.1866-1874.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Transcriptome of Treponema pallidum: Gene Expression Profile during Experimental Rabbit Infection{dagger}

David Smajs,1,2* Matthew McKevitt,3 Jerrilyn K. Howell,4 Steven J. Norris,4 Wei-Wen Cai,5 Timothy Palzkill,3 and George M. Weinstock1

Human Genome Sequencing Center,1 Department of Molecular Virology and Microbiology,3 Department of Molecular and Human Genetics, Baylor College of Medicine,5 Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas,4 Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic2

Received 30 March 2004/ Accepted 18 October 2004

RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T. pallidum transcriptome during experimental infection provides further insight into the importance of gene expression levels for the survival and pathogenesis of this bacterium.

* Corresponding author. Mailing address: Department of Biology, Faculty of Medicine, Masaryk University, Tomesova 12, 602 00 Brno, Czech Republic. Phone: 420 549 497 496. Fax: 420 549 497 070. E-mail: dsmajs{at}med.muni.cz.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, March 2005, p. 1866-1874, Vol. 187, No. 5
0021-9193/05/$08.00+0     doi:10.1128/JB.187.5.1866-1874.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Strouhal, M., Smajs, D., Matejkova, P., Sodergren, E., Amin, A. G., Howell, J. K., Norris, S. J., Weinstock, G. M. (2007). Genome Differences between Treponema pallidum subsp. pallidum Strain Nichols and T. paraluiscuniculi Strain Cuniculi A. Infect. Immun. 75: 5859-5866 [Abstract] [Full Text]  
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