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Journal of Bacteriology, March 2005, p. 1866-1874, Vol. 187, No. 5
0021-9193/05/$08.00+0     doi:10.1128/JB.187.5.1866-1874.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Transcriptome of Treponema pallidum: Gene Expression Profile during Experimental Rabbit Infection

David majs,^1,2* Matthew McKevitt,³ Jerrilyn K. Howell,⁴ Steven J. Norris,⁴ Wei-Wen Cai,⁵ Timothy Palzkill,³ and George M. Weinstock¹

Human Genome Sequencing Center,¹ Department of Molecular Virology and Microbiology,³ Department of Molecular and Human Genetics, Baylor College of Medicine,⁵ Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas,⁴ Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic²

Received 30 March 2004/ Accepted 18 October 2004

RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T. pallidum transcriptome during experimental infection provides further insight into the importance of gene expression levels for the survival and pathogenesis of this bacterium.

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