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Journal of Bacteriology, March 2005, p. 2200-2202, Vol. 187, No. 6
0021-9193/05/$08.00+0     doi:10.1128/JB.187.6.2200-2202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Mutation in the Decoding Center of Thermus thermophilus 16S rRNA Suggests a Novel Mechanism of Streptomycin Resistance

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island

Received 11 October 2004/ Accepted 1 December 2004

A spontaneous kanamycin resistance and capreomycin resistance mutation, A1408G, in the decoding center of 16S rRNA, was identified in the extreme thermophile Thermus thermophilus. Unexpectedly, this mutation also confers resistance to streptomycin. We propose a novel mechanism of streptomycin resistance by which A1408G influences conformational changes in 16S rRNA during tRNA selection.

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