This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chistoserdova, L. Articles by Lidstrom, M. E. Search for Related Content PubMed PubMed Citation Articles by Chistoserdova, L. Articles by Lidstrom, M. E.

Novel Dephosphotetrahydromethanopterin Biosynthesis Genes Discovered via Mutagenesis in Methylobacterium extorquens AM1

Department of Chemical Engineering,¹ Department of Microbiology, University of Washington, Seattle, Washington,³ Microbiology and Cell Science Department, University of Florida, Gainesville, Florida²

Received 11 October 2004/ Accepted 14 December 2004

Methylobacterium extorquens AM1 was used to explore the genetics of dephosphotetrahydromethanopterin (dH₄MPT) biosynthesis. Strains with mutations in eight "archaeal-type" genes linked on the chromosome of M. extorquens AM1 were analyzed for the ability to synthesize dH₄MPT, and six were found to be dH₄MPT negative. Putative functions of these genes in dH₄MPT biosynthesis are discussed.

This article has been cited by other articles:

• Vorholt, J. A., Kalyuzhnaya, M. G., Hagemeier, C. H., Lidstrom, M. E., Chistoserdova, L. (2005). MtdC, a Novel Class of Methylene Tetrahydromethanopterin Dehydrogenases. J. Bacteriol. 187: 6069-6074 [Abstract] [Full Text]  
• Kalyuzhnaya, M. G., Korotkova, N., Crowther, G., Marx, C. J., Lidstrom, M. E., Chistoserdova, L. (2005). Analysis of Gene Islands Involved in Methanopterin-Linked C1 Transfer Reactions Reveals New Functions and Provides Evolutionary Insights. J. Bacteriol. 187: 4607-4614 [Abstract] [Full Text]