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Journal of Bacteriology, April 2005, p. 2540-2550, Vol. 187, No. 7
0021-9193/05/$08.00+0     doi:10.1128/JB.187.7.2540-2550.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Transcriptional Analysis of the Principal Cell Division Gene, ftsZ, of Mycobacterium tuberculosis

Sougata Roy1 and Parthasarathi Ajitkumar1*

Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India1

Received 23 September 2004/ Accepted 23 December 2004

Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.

* Corresponding author. Mailing address: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore-560012, India. Phone: 91-80-22932344. Fax: 91-80-23602697. E-mail: ajit{at}mcbl.iisc.ernet.in.

Journal of Bacteriology, April 2005, p. 2540-2550, Vol. 187, No. 7
0021-9193/05/$08.00+0     doi:10.1128/JB.187.7.2540-2550.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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