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Journal of Bacteriology, April 2005, p. 2903-2907, Vol. 187, No. 8
0021-9193/05/$08.00+0     doi:10.1128/JB.187.8.2903-2907.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Role of the Rep Helicase Gene in Homologous Recombination in Neisseria gonorrhoeae

Kimberly A. Kline and H. Steven Seifert*

Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Received 10 November 2004/ Accepted 10 January 2005

In Escherichia coli, the Rep helicase has been implicated in replication fork progression, replication restart, homologous recombination, and DNA repair. We show that a Neisseria gonorrhoeae rep mutant is deficient in the homologous-recombination-mediated processes of DNA transformation and pilus-based colony variation but not in DNA repair.

* Corresponding author. Mailing address: Department of Microbiology-Immunology, Northwestern University Feinberg University School of Medicine, 303 East Chicago Ave., Searle 6-450, Chicago, IL 60611. Phone: (312) 503-9788. Fax: (312) 503-1339. E-mail: h-seifert{at}northwestern.edu.

Journal of Bacteriology, April 2005, p. 2903-2907, Vol. 187, No. 8
0021-9193/05/$08.00+0     doi:10.1128/JB.187.8.2903-2907.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kline, K. A., Criss, A. K., Wallace, A., Seifert, H. S. (2007). Transposon Mutagenesis Identifies Sites Upstream of the Neisseria gonorrhoeae pilE Gene That Modulate Pilin Antigenic Variation. J. Bacteriol. 189: 3462-3470 [Abstract] [Full Text]  
  • Stohl, E. A., Seifert, H. S. (2006). Neisseria gonorrhoeae DNA Recombination and Repair Enzymes Protect against Oxidative Damage Caused by Hydrogen Peroxide. J. Bacteriol. 188: 7645-7651 [Abstract] [Full Text]  
  • Kline, K. A., Seifert, H. S. (2005). Mutation of the priA Gene of Neisseria gonorrhoeae Affects DNA Transformation and DNA Repair. J. Bacteriol. 187: 5347-5355 [Abstract] [Full Text]  
  • Rohrer, M. S., Lazio, M. P., Seifert, H. S. (2005). A real-time semi-quantitative RT-PCR assay demonstrates that the pilE sequence dictates the frequency and characteristics of pilin antigenic variation in Neisseria gonorrhoeae. Nucleic Acids Res 33: 3363-3371 [Abstract] [Full Text]  


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