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Global Gene Expression Responses to Cadmium Toxicity in Escherichia coli

Anyou Wang and David E. Crowley^*

Department of Environmental Sciences, University of California, Riverside, California 92521

Received 8 October 2004/ Accepted 19 January 2005

Genome-wide analysis of temporal gene expression profiles in Escherichia coli following exposure to cadmium revealed a shift to anaerobic metabolism and induction of several stress response systems. Disruption in the transcription of genes encoding ribosomal proteins and zinc-binding proteins may partially explain the molecular mechanisms of cadmium toxicity.

Present address: Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720.

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