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Journal of Bacteriology, May 2005, p. 3259-3266, Vol. 187, No. 9
0021-9193/05/$08.00+0     doi:10.1128/JB.187.9.3259-3266.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Global Gene Expression Responses to Cadmium Toxicity in Escherichia coli

Anyou Wang{dagger} and David E. Crowley*

Department of Environmental Sciences, University of California, Riverside, California 92521

Received 8 October 2004/ Accepted 19 January 2005

Genome-wide analysis of temporal gene expression profiles in Escherichia coli following exposure to cadmium revealed a shift to anaerobic metabolism and induction of several stress response systems. Disruption in the transcription of genes encoding ribosomal proteins and zinc-binding proteins may partially explain the molecular mechanisms of cadmium toxicity.


* Corresponding author. Mailing address: Department of Environmental Sciences, University of Caliifornia, Riverside, CA 92521. Phone: (909) 787-3785. Fax: (909) 787-3993. E-mail: crowley{at}ucr.edu.

{dagger} Present address: Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720.


Journal of Bacteriology, May 2005, p. 3259-3266, Vol. 187, No. 9
0021-9193/05/$08.00+0     doi:10.1128/JB.187.9.3259-3266.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




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