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Journal of Bacteriology, May 2006, p. 3716-3720, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3716-3720.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Evidence that Clostridium difficile TcdC Is a Membrane-Associated Protein

Revathi Govind, Govindsamy Vediyappan, Rial D. Rolfe, and Joe A. Fralick*

Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430

Received 31 December 2005/ Accepted 1 March 2006

Clostridium difficile produces two toxins, A and B, which act together to cause pseudomembraneous colitis. The genes encoding these toxins, tcdA and tcdB, are part of the pathogenicity locus, which also includes tcdC, a putative negative regulator of the toxin genes. In this study, we demonstrate that TcdC is a membrane-associated protein in C. difficile.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430. Phone: (806) 743-2555. Fax: (806) 743-2334. E-mail: joe.fralick{at}ttuhsc.edu.

Journal of Bacteriology, May 2006, p. 3716-3720, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3716-3720.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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