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Journal of Bacteriology, May 2006, p. 3721-3725, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3721-3725.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo{dagger}

Veerabadran Dheenadhayalan,1 Giovanni Delogu,2 Maurizio Sanguinetti,2 Giovanni Fadda,2 and Michael J. Brennan1*

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland,1 Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy2

Received 27 January 2006/ Accepted 1 March 2006

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

* Corresponding author. Mailing address: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg. 29, Rm. 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892. Phone: (301) 496-9559. Fax: (301) 435-5675. E-mail: michael.brennan{at}fda.hhs.gov.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, May 2006, p. 3721-3725, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3721-3725.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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