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 Previous Article

Journal of Bacteriology, May 2006, p. 3726-3729, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3726-3729.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Initiates the Stringent Response upon Nutrient and pH Downshift

Derek H. Wells1,{dagger} and Erin C. Gaynor2*

Department of Biological Sciences, Stanford University, Stanford, California,1 Department of Microbiology and Immunology, Stanford University, Stanford, California2

Received 31 August 2005/ Accepted 2 March 2006

Helicobacter pylori was previously reported to lack a stringent response. In contrast, we show that after nutrient downshift, H. pylori produced abundant ppGpp and less total RNA. pH downshift also caused (p)ppGpp accumulation. Our observations indicate that nutrient deprivation and acid shock activate the stringent response in H. pylori.

* Corresponding author. Present address: Department of Microbiology and Immunology, University of British Columbia, Life Sciences Centre, 2558-2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. Phone: (604) 822-2710. Fax: (604) 822-6041. E-mail: egaynor{at}interchange.ubc.ca.

{dagger} Present address: Division of Infectious Diseases, University of California San Francisco, San Francisco, California.

Journal of Bacteriology, May 2006, p. 3726-3729, Vol. 188, No. 10
0021-9193/06/$08.00+0     doi:10.1128/JB.188.10.3726-3729.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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