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Journal of Bacteriology, July 2006, p. 4992-4995, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00281-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Involvement of Y-Family DNA Polymerases in Mutagenesis Caused by Oxidized Nucleotides in Escherichia coli

Masami Yamada,1 Tatsuo Nunoshiba,2 Masatomi Shimizu,1,3 Petr Gruz,1 Hiroyuki Kamiya,4 Hideyoshi Harashima,4 and Takehiko Nohmi1*

Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan,1 Graduate School of Life Sciences, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan,2 Tokyo Healthcare University, 3-11-3, Setagaya, Setagaya-ku, Tokyo 154-8568, Japan,3 Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nihi-6, Kita-ku, Sapporo 060-0812, Japan4

Received 22 February 2006/ Accepted 11 April 2006

Escherichia coli DNA polymerase IV incorporated 2-hydroxy-dATP opposite template guanine or thymine and 8-hydroxy-dGTP exclusively opposite adenine in vitro. Mutator phenotypes in sod/fur strains were substantially diminished by deletion of dinB and/or umuDC. DNA polymerases IV and V may be involved in mutagenesis caused by incorporation of the oxidized deoxynucleoside triphosphates.

* Corresponding author. Mailing address: Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. Phone: (81) 3 3700 9873. Fax: (81) 3 3707 6950. E-mail: nohmi{at}nihs.go.jp.

Journal of Bacteriology, July 2006, p. 4992-4995, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00281-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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