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Journal of Bacteriology, July 2006, p. 4996-5001, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00317-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Interference between Streptococcus pneumoniae and Staphylococcus aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus pneumoniae

Gili Regev-Yochay,^1* Krzysztof Trzciski,¹ Claudette M. Thompson,¹ Richard Malley,² and Marc Lipsitch¹

Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts,¹ Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts²

Received 3 March 2006/ Accepted 21 April 2006

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.

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