This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Regev-Yochay, G.
Right arrow Articles by Lipsitch, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Regev-Yochay, G.
Right arrow Articles by Lipsitch, M.

 Previous Article

Journal of Bacteriology, July 2006, p. 4996-5001, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00317-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Interference between Streptococcus pneumoniae and Staphylococcus aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus pneumoniae

Gili Regev-Yochay,1* Krzysztof Trzcinski,1 Claudette M. Thompson,1 Richard Malley,2 and Marc Lipsitch1

Department of Epidemiology and Department of Immunology & Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts,1 Division of Infectious Diseases, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, Massachusetts2

Received 3 March 2006/ Accepted 21 April 2006

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.


* Corresponding author. Mailing address: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115. Phone: (617) 432-3269. E-mail: gregev{at}hsph.harvard.edu.


Journal of Bacteriology, July 2006, p. 4996-5001, Vol. 188, No. 13
0021-9193/06/$08.00+0     doi:10.1128/JB.00317-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Cornejo, O. E, Rozen, D. E, May, R. M, Levin, B. R (2009). Oscillations in continuous culture populations of Streptococcus pneumoniae: population dynamics and the evolution of clonal suicide. Proc R Soc B 276: 999-1008 [Abstract] [Full Text]  
  • Hakeem, L. M, Urolagin, M., Bhattacharyya, D. N, Campbell, I. W, Griffiths, G. (2009). Haemorrhagic bullous Streptococcus pneumoniae cellulitis in type 2 diabetes mellitus. British Journal of Diabetes & Vascular Disease 9: 75-79 [Abstract]  
  • Selva, L., Viana, D., Regev-Yochay, G., Trzcinski, K., Corpa, J. M., Lasa, i., Novick, R. P., Penades, J. R. (2009). Killing niche competitors by remote-control bacteriophage induction. Proc. Natl. Acad. Sci. USA 106: 1234-1238 [Abstract] [Full Text]  
  • Margolis, E. (2009). Hydrogen Peroxide-Mediated Interference Competition by Streptococcus pneumoniae Has No Significant Effect on Staphylococcus aureus Nasal Colonization of Neonatal Rats. J. Bacteriol. 191: 571-575 [Abstract] [Full Text]  
  • Kreth, J., Zhang, Y., Herzberg, M. C. (2008). Streptococcal Antagonism in Oral Biofilms: Streptococcus sanguinis and Streptococcus gordonii Interference with Streptococcus mutans. J. Bacteriol. 190: 4632-4640 [Abstract] [Full Text]  
  • Trzcinski, K., Thompson, C. M., Srivastava, A., Basset, A., Malley, R., Lipsitch, M. (2008). Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4+ T Cells. Infect. Immun. 76: 2678-2684 [Abstract] [Full Text]  
  • Park, B., Nizet, V., Liu, G. Y. (2008). Role of Staphylococcus aureus Catalase in Niche Competition against Streptococcus pneumoniae. J. Bacteriol. 190: 2275-2278 [Abstract] [Full Text]  
  • Regev-Yochay, G., Malley, R., Rubinstein, E., Raz, M., Dagan, R., Lipsitch, M. (2008). In Vitro Bactericidal Activity of Streptococcus pneumoniae and Bactericidal Susceptibility of Staphylococcus aureus Strains Isolated from Cocolonized versus Noncocolonized Children. J. Clin. Microbiol. 46: 747-749 [Abstract] [Full Text]  
  • Regev-Yochay, G., Trzcinski, K., Thompson, C. M., Lipsitch, M., Malley, R. (2007). SpxB Is a Suicide Gene of Streptococcus pneumoniae and Confers a Selective Advantage in an In Vivo Competitive Colonization Model. J. Bacteriol. 189: 6532-6539 [Abstract] [Full Text]  
  • Gruner, B. M., Han, S.-R., Meyer, H.-G., Wulf, U., Bhakdi, S., Siegel, E. K. (2007). Characterization of a Catalase-Negative Methicillin-Resistant Staphylococcus aureus Strain. J. Clin. Microbiol. 45: 2684-2685 [Abstract] [Full Text]  
  • Melles, D. C., Bogaert, D., Gorkink, R. F. J., Peeters, J. K., Moorhouse, M. J., Ott, A., van Leeuwen, W. B., Simons, G., Verbrugh, H. A., Hermans, P. W. M., van Belkum, A. (2007). Nasopharyngeal co-colonization with Staphylococcus aureus and Streptococcus pneumoniae in children is bacterial genotype independent. Microbiology 153: 686-692 [Abstract] [Full Text]