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Journal of Bacteriology, July 2006, p. 5319-5324, Vol. 188, No. 14
0021-9193/06/$08.00+0     doi:10.1128/JB.01662-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Population Structure of Francisella tularensis{dagger}

Ulrich Nübel,1* Rolf Reissbrodt,1 Annette Weller,1 Roland Grunow,2,{ddagger} Mustafa Porsch-Özcürümez,2 Herbert Tomaso,2 Erwin Hofer,3 Wolf Splettstoesser,2,4 Ernst-Jürgen Finke,2 Helmut Tschäpe,1 and Wolfgang Witte1

Robert Koch Institute, Wernigerode, Germany,1 Bundeswehr Institute of Microbiology, München, Germany,2 Austrian Agency for Health and Food Safety, Mödling, Austria,3 Department of Microbiology, University Hospital, Rostock, Germany4

Received 1 November 2005/ Accepted 28 April 2006

We have sequenced fragments of five metabolic housekeeping genes and two genes encoding outer membrane proteins from 81 isolates of Francisella tularensis, representing all four subspecies. Phylogenetic clustering of gene sequences from F. tularensis subsp. tularensis and F. tularensis subsp. holarctica aligned well with subspecies affiliations. In contrast, F. tularensis subsp. novicida and F. tularensis subsp. mediasiatica were indicated to be phylogenetically incoherent taxa. Incongruent gene trees and mosaic structures of housekeeping genes provided evidence for genetic recombination in F. tularensis.

* Corresponding author: Robert Koch Institute, Burgstr. 37, 38855 Wernigerode, Germany. Phone: 03943-679338. Fax: 03943-679317. E-mail: nuebelu{at}rki.de.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

{ddagger} Present address: Robert Koch Institute, Berlin, Germany.

Journal of Bacteriology, July 2006, p. 5319-5324, Vol. 188, No. 14
0021-9193/06/$08.00+0     doi:10.1128/JB.01662-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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