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Journal of Bacteriology, August 2006, p. 5632-5634, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00438-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Straight-Chain Fatty Acids Are Dispensable in the Myxobacterium Myxococcus xanthus for Vegetative Growth and Fruiting Body Formation

Helge B. Bode,1* Michael W. Ring,1 Dale Kaiser,2 Anna C. David,1 Reiner M. Kroppenstedt,3 and Gertrud Schwär1

Institut für Pharmazeutische Biotechnologie, Universität des Saarlandes, 66041 Saarbrücken, Germany,1 Departments of Biochemistry and Developmental Biology, Stanford University, Stanford, California 94305,2 Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ), 38124 Braunschweig, Germany3

Received 30 March 2006/ Accepted 15 May 2006

Inactivation of the MXAN_0853 gene blocked the production in Myxococcus xanthus of straight-chain fatty acids which otherwise represent 30% of total fatty acids. Despite this drastic change in the fatty acid profile, no change in phenotype could be observed, which contrasts with previous interpretations of the role of straight-chain fatty acids in the organism's development.


* Corresponding author. Mailing address: Institut für Pharmazeutische Biotechnologie, Universität des Saarlandes, P.O. Box 151150, 66041 Saarbrücken, Germany. Phone: 49 681 3025494. Fax: 49 681 3025473. E-mail: h.bode{at}mx.uni-saarland.de.


Journal of Bacteriology, August 2006, p. 5632-5634, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00438-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.




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  • Bode, H. B., Ring, M. W., Schwar, G., Kroppenstedt, R. M., Kaiser, D., Muller, R. (2006). 3-Hydroxy-3-Methylglutaryl-Coenzyme A (CoA) Synthase Is Involved in Biosynthesis of Isovaleryl-CoA in the Myxobacterium Myxococcus xanthus during Fruiting Body Formation.. J. Bacteriol. 188: 6524-6528 [Abstract] [Full Text]