This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Whitby, P. W.
Right arrow Articles by Stull, T. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitby, P. W.
Right arrow Articles by Stull, T. L.

 Previous Article  |  Next Article 

Journal of Bacteriology, August 2006, p. 5640-5645, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00417-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transcriptional Profile of Haemophilus influenzae: Effects of Iron and Heme

Paul W. Whitby,1 Timothy M. VanWagoner,1 Thomas W. Seale,1 Daniel J. Morton,1 and Terrence L. Stull1,2*

Departments of Pediatrics,1 Microbiology/Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 731042

Received 24 March 2006/ Accepted 23 May 2006

Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing ~10% of the genome, with ≥1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

* Corresponding author. Mailing address: Department of Pediatrics, CHO 2308, 940 NE 13th St., Oklahoma City, OK 73104. Phone: (405) 271-4401. Fax: (405) 271-8710. E-mail: tstull{at}ouhsc.edu.

Journal of Bacteriology, August 2006, p. 5640-5645, Vol. 188, No. 15
0021-9193/06/$08.00+0     doi:10.1128/JB.00417-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Morton, D. J., Seale, T. W., Madore, L. L., VanWagoner, T. M., Whitby, P. W., Stull, T. L. (2007). The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae. Microbiology 153: 215-224 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»