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Journal of Bacteriology, September 2006, p. 6440-6442, Vol. 188, No. 17
0021-9193/06/$08.00+0     doi:10.1128/JB.00741-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Residues Involved in FecR Binding Are Localized on One Side of the FecA Signaling Domain in Escherichia coli

Microbiology/Membrane Physiology, University of Tübingen, D-72076 Tübingen, Germany

Received 23 May 2006/ Accepted 22 June 2006

Ferric citrate transport in Escherichia coli involves proteins encoded by the fec genes, including the transport and signaling protein FecA and the signal transducing protein FecR. Randomly isolated FecA point mutants showed a reduced interaction with FecR and a reduced transcription initiation of the ferric citrate transport genes. The mutations were localized on one side of the FecA signaling domain, which might form the interface to FecR. Some of the mutants showed strongly reduced iron transport rates, which suggests that the signaling domain affects the structure of the FecA transporter domain.

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