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Journal of Bacteriology, September 2006, p. 6443-6448, Vol. 188, No. 17
0021-9193/06/$08.00+0     doi:10.1128/JB.00266-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Superoxide Dismutase B Gene (sodB)-Deficient Mutants of Francisella tularensis Demonstrate Hypersensitivity to Oxidative Stress and Attenuated Virulence

Chandra Shekhar Bakshi,1* Meenakshi Malik,1 Kevin Regan,1 J. Andres Melendez,1 Dennis W. Metzger,1 Vitaly M. Pavlov,2 and Timothy J. Sellati1*

Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208,1 State Research Center for Applied Microbiology, Obolensk, Russia2

Received 20 February 2006/ Accepted 26 June 2006

A Francisella tularensis live vaccine strain mutant (sodBFt) with reduced Fe-superoxide dismutase gene expression was generated and found to exhibit decreased sodB activity and increased sensitivity to redox cycling compounds compared to wild-type bacteria. The sodBFt mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor.

* Corresponding author. Mailing address: Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208-3479. Phone for Timothy J. Sellati: (518) 262-8140. Fax: (518) 262-2885. E-mail: sellatt{at}mail.amc.edu. Phone for Chandra Shekhar Bakshi: (518) 262-6263. Fax: (518) 262-6161. E-mail: bakshis{at}mail.amc.edu.

Journal of Bacteriology, September 2006, p. 6443-6448, Vol. 188, No. 17
0021-9193/06/$08.00+0     doi:10.1128/JB.00266-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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