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Journal of Bacteriology, September 2006, p. 6709-6713, Vol. 188, No. 18
0021-9193/06/$08.00+0     doi:10.1128/JB.00680-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transcriptional Response of Escherichia coli to TPEN

Tara K. Sigdel, J. Allen Easton, and Michael W. Crowder*

Department of Chemistry and Biochemistry, 160 Hughes Hall, Miami University, Oxford, Ohio 45056

Received 12 May 2006/ Accepted 4 July 2006

DNA microarrays were used to probe the transcriptional response of Escherichia coli to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Fifty-five transcripts were significantly up-regulated, including all of the genes that are regulated by Zur and many that are regulated by Fur. In the same TPEN-treated cells, 46 transcripts were significantly down-regulated.

* Corresponding author. Mailing address: Department of Chemistry and Biochemistry, 160 Hughes Hall, Miami University, Oxford, OH 45056. Phone: (513) 529-7274. Fax: (513) 529-5715. E-mail: crowdemw{at}muohio.edu.

Journal of Bacteriology, September 2006, p. 6709-6713, Vol. 188, No. 18
0021-9193/06/$08.00+0     doi:10.1128/JB.00680-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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