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Journal of Bacteriology, October 2006, p. 7022-7025, Vol. 188, No. 19
0021-9193/06/$08.00+0     doi:10.1128/JB.00687-06

Modes of Regulation of RpoS by H-NS{dagger}

YanNing Zhou and Susan Gottesman*

Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892

Received 15 May 2006/ Accepted 2 July 2006

Regulated degradation of RpoS requires RssB and ClpXP protease. Mutations in hns increase both RpoS synthesis and stability, causing a twofold increase in synthesis and almost complete stabilization of RpoS, independent of effects on synthesis and independent of phosphorylation of RssB. This suggests that H-NS regulates an RssB inhibitor or inhibitors.

* Corresponding author. Mailing address: Bldg. 37, Rm. 5132, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 496-3524. Fax: (301) 496-3875. E-mail: susang{at}helix.nih.gov.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, October 2006, p. 7022-7025, Vol. 188, No. 19
0021-9193/06/$08.00+0     doi:10.1128/JB.00687-06




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