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Journal of Bacteriology, October 2006, p. 7022-7025, Vol. 188, No. 19
0021-9193/06/$08.00+0 doi:10.1128/JB.00687-06
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892
Received 15 May 2006/ Accepted 2 July 2006
Regulated degradation of RpoS requires RssB and ClpXP protease. Mutations in hns increase both RpoS synthesis and stability, causing a twofold increase in synthesis and almost complete stabilization of RpoS, independent of effects on synthesis and independent of phosphorylation of RssB. This suggests that H-NS regulates an RssB inhibitor or inhibitors.
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