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Journal of Bacteriology, October 2006, p. 7026-7032, Vol. 188, No. 19
0021-9193/06/$08.00+0     doi:10.1128/JB.00643-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification and Characterization of a Major Zn(II) Resistance Determinant of Mycobacterium smegmatis

Amit Grover and Rakesh Sharma*

Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India

Received 5 May 2006/ Accepted 18 July 2006

A zinc ion-sensitive mutant of Mycobacterium smegmatis was isolated. The transposon insertion was located in zitA (MSMEG0750), a gene coding for a cation diffusion facilitator family protein. Zinc ions specifically induced expression of zitA. In silico analysis revealed that environmental and opportunistic pathogenic species contain higher numbers of cation diffusion facilitator genes than do obligate pathogens.

* Corresponding author. Mailing address: Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India. Phone: 91-11-27666156. Fax: 91-11-27667174. E-mail: rsharma{at}igib.res.in.

Journal of Bacteriology, October 2006, p. 7026-7032, Vol. 188, No. 19
0021-9193/06/$08.00+0     doi:10.1128/JB.00643-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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