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Agr Interference between Clinical Staphylococcus aureus Strains in an Insect Model of Virulence^,

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom,¹ Peter Medawar Building, Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, United Kingdom,² Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand,³ Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom⁴

Received 17 May 2006/ Accepted 16 August 2006

Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.

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Published ahead of print on 25 August 2006.

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