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Journal of Bacteriology, November 2006, p. 7977-7980, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.01088-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of DNA Polymerase IV in Escherichia coli SOS Mutator Activity{triangledown}

Wojciech Kuban,1 Magdalena Banach-Orlowska,1 Roel M. Schaaper,2 Piotr Jonczyk,1 and Iwona J. Fijalkowska1*

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02 106 Warsaw, Poland,1 Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 277092

Received 22 July 2006/ Accepted 8 September 2006

Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product).

* Corresponding author. Mailing address: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A 02 106 Warsaw, Poland. Phone: (48) 22-592-1113. Fax: (48) 22-658-4636. E-mail: iwonaf{at}ibb.waw.pl.

{triangledown} Published ahead of print on 15 September 2006.

Journal of Bacteriology, November 2006, p. 7977-7980, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.01088-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Galhardo, R. S., Do, R., Yamada, M., Friedberg, E. C., Hastings, P. J., Nohmi, T., Rosenberg, S. M. (2009). DinB Upregulation Is the Sole Role of the SOS Response in Stress-Induced Mutagenesis in Escherichia coli. Genetics 182: 55-68 [Abstract] [Full Text]  


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