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Journal of Bacteriology, November 2006, p. 7988-7991, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.00791-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Transcription Modulation of Salmonella enterica Serovar Typhimurium Promoters by Sub-MIC Levels of Rifampin{triangledown}

Grace Yim,1 Fernando de la Cruz,2 George B. Spiegelman,1 and Julian Davies1*

Department of Microbiology and Immunology, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada,1 Departamento de Biología Molecular, Universidad de Cantabria, C. Herrera Oria s/n, Santander 39011, Spain2

Received 1 June 2006/ Accepted 5 September 2006

Promoter-lux fusions that showed rifampin-modulated transcription were identified from a Salmonella enterica serovar Typhimurium 14028 reporter library. The transformation of a subset of fusions into mutants that lacked one of six global regulatory proteins or were rifampin resistant showed that transcription modulation was independent of the global regulators, promoter specific, and dependent on the interaction of rifampin with RNA polymerase.

* Corresponding author. Mailing address: Dept. of Microbiology and Immunology, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada. Phone: (604) 822-5856. Fax: (604) 822-6041. E-mail: jed{at}interchange.ubc.ca.

{triangledown} Published ahead of print on 15 September 2006.

Journal of Bacteriology, November 2006, p. 7988-7991, Vol. 188, No. 22
0021-9193/06/$08.00+0     doi:10.1128/JB.00791-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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