This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seshadri, R.
Right arrow Articles by Heidelberg, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seshadri, R.
Right arrow Articles by Heidelberg, J. F.

 Previous Article  |  Next Article 

Journal of Bacteriology, December 2006, p. 8272-8282, Vol. 188, No. 23
0021-9193/06/$08.00+0     doi:10.1128/JB.00621-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genome Sequence of Aeromonas hydrophila ATCC 7966T: Jack of All Trades{triangledown}

Rekha Seshadri,1* Sam W. Joseph,2 Ashok K. Chopra,7 Jian Sha,7 Jonathan Shaw,5 Joerg Graf,6 Daniel Haft,1 Martin Wu,1 Qinghu Ren,1 M. J. Rosovitz,1 Ramana Madupu,1 Luke Tallon,1 Mary Kim,1 Shaohua Jin,1 Hue Vuong,1 O. Colin Stine,3 Afsar Ali,3 Amy J. Horneman,3,4,{dagger}* and John F. Heidelberg1,2,{dagger},{ddagger}

The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850,1 Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742,2 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201,3 Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland,4 Division of Genomic Medicine, Section of Functional Genomics, University of Sheffield Medical School, Sheffield, S10 2RX, United Kingdom,5 Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269,6 Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 775557

Received 2 May 2006/ Accepted 6 September 2006

The complete genome of Aeromonas hydrophila ATCC 7966T was sequenced. Aeromonas, a ubiquitous waterborne bacterium, has been placed by the Environmental Protection Agency on the Contaminant Candidate List because of its potential to cause human disease. The 4.7-Mb genome of this emerging pathogen shows a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer upon this organism the ability to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagellum, that are reported in other A. hydrophila strains are not identified in the sequenced isolate, ATCC 7966T. Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, and phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative as well as industrial potential. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments.

* Corresponding author. Present address for Rekha Seshadri: J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850. Phone: (240) 268-2856. Fax: (240) 268-4000. E-mail: rseshadri{at}venterinstitute.org. Mailing address for Amy Horneman: 10 S. Pine Street, MSTF 900D, Baltimore, MD 21201. Phone: (410) 706-1176. Fax: (410) 706-4581. E-mail: ahornema{at}epi.umaryland.edu.

{triangledown} Published ahead of print on 15 September 2006.

{dagger} A.J.H. and J.F.H. contributed equally to the manuscript.

{ddagger} Present address: Department of Biological Sciences, Philip K. Wrigley Marine Science Center, University of Southern California, Avalon, CA 90704.

Journal of Bacteriology, December 2006, p. 8272-8282, Vol. 188, No. 23
0021-9193/06/$08.00+0     doi:10.1128/JB.00621-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jimenez, N., Vilches, S., Lacasta, A., Regue, M., Merino, S., Tomas, J. M. (2009). A Bifunctional Enzyme in a Single Gene Catalyzes the Incorporation of GlcN into the Aeromonas Core Lipopolysaccharide. J. Biol. Chem. 284: 32995-33005 [Abstract] [Full Text]  
  • Khajanchi, B. K., Sha, J., Kozlova, E. V., Erova, T. E., Suarez, G., Sierra, J. C., Popov, V. L., Horneman, A. J., Chopra, A. K. (2009). N-Acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila. Microbiology 155: 3518-3531 [Abstract] [Full Text]  
  • Kobayashi, H., Utsunomiya, H., Yamanaka, H., Sei, Y., Katunuma, N., Okamoto, K., Tsuge, H. (2009). Structural Basis for the Kexin-like Serine Protease from Aeromonas sobria as Sepsis-causing Factor. J. Biol. Chem. 284: 27655-27663 [Abstract] [Full Text]  
  • Burr, S. E., Frey, J. (2009). Aeromonas salmonicida subsp. salmonicida Type Strain Does Not Possess a Type III Secretion System. J. Clin. Microbiol. 47: 3062-3063 [Full Text]  
  • Sha, J., Erova, T. E., Alyea, R. A., Wang, S., Olano, J. P., Pancholi, V., Chopra, A. K. (2009). Surface-Expressed Enolase Contributes to the Pathogenesis of Clinical Isolate SSU of Aeromonas hydrophila. J. Bacteriol. 191: 3095-3107 [Abstract] [Full Text]  
  • Tabei, S. M. B., Hitchen, P. G., Day-Williams, M. J., Merino, S., Vart, R., Pang, P.-C., Horsburgh, G. J., Viches, S., Wilhelms, M., Tomas, J. M., Dell, A., Shaw, J. G. (2009). An Aeromonas caviae Genomic Island Is Required for both O-Antigen Lipopolysaccharide Biosynthesis and Flagellin Glycosylation. J. Bacteriol. 191: 2851-2863 [Abstract] [Full Text]  
  • Jimenez, N., Lacasta, A., Vilches, S., Reyes, M., Vazquez, J., Aquillini, E., Merino, S., Regue, M., Tomas, J. M. (2009). Genetics and Proteomics of Aeromonas salmonicida Lipopolysaccharide Core Biosynthesis. J. Bacteriol. 191: 2228-2236 [Abstract] [Full Text]  
  • Alexandre, A., Laranjo, M., Young, J. P. W., Oliveira, S. (2008). dnaJ is a useful phylogenetic marker for alphaproteobacteria. Int. J. Syst. Evol. Microbiol. 58: 2839-2849 [Abstract] [Full Text]  
  • Kudryashov, D. S., Durer, Z. A. O., Ytterberg, A. J., Sawaya, M. R., Pashkov, I., Prochazkova, K., Yeates, T. O., Loo, R. R. O., Loo, J. A., Satchell, K. J. F., Reisler, E. (2008). Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. Proc. Natl. Acad. Sci. USA 105: 18537-18542 [Abstract] [Full Text]  
  • Mey, A. R., Wyckoff, E. E., Hoover, L. A., Fisher, C. R., Payne, S. M. (2008). Vibrio cholerae VciB Promotes Iron Uptake via Ferrous Iron Transporters. J. Bacteriol. 190: 5953-5962 [Abstract] [Full Text]  
  • Gordon, L., Cloeckaert, A., Doublet, B., Schwarz, S., Bouju-Albert, A., Ganiere, J.-P., Le Bris, H., Le Fleche-Mateos, A., Giraud, E. (2008). Complete sequence of the floR-carrying multiresistance plasmid pAB5S9 from freshwater Aeromonas bestiarum. J Antimicrob Chemother 62: 65-71 [Abstract] [Full Text]  
  • Adin, D. M., Visick, K. L., Stabb, E. V. (2008). Identification of a Cellobiose Utilization Gene Cluster with Cryptic {beta}-Galactosidase Activity in Vibrio fischeri. Appl. Environ. Microbiol. 74: 4059-4069 [Abstract] [Full Text]  
  • Erova, T. E., Kosykh, V. G., Fadl, A. A., Sha, J., Horneman, A. J., Chopra, A. K. (2008). Cold Shock Exoribonuclease R (VacB) Is Involved in Aeromonas hydrophila Pathogenesis. J. Bacteriol. 190: 3467-3474 [Abstract] [Full Text]  
  • Jimenez, N., Canals, R., Lacasta, A., Kondakova, A. N., Lindner, B., Knirel, Y. A., Merino, S., Regue, M., Tomas, J. M. (2008). Molecular Analysis of Three Aeromonas hydrophila AH-3 (Serotype O34) Lipopolysaccharide Core Biosynthesis Gene Clusters. J. Bacteriol. 190: 3176-3184 [Abstract] [Full Text]  
  • Hernould, M., Gagne, S., Fournier, M., Quentin, C., Arpin, C. (2008). Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance. Antimicrob. Agents Chemother. 52: 1559-1563 [Abstract] [Full Text]  
  • Nuccio, S.-P., Baumler, A. J. (2007). Evolution of the Chaperone/Usher Assembly Pathway: Fimbrial Classification Goes Greek. Microbiol. Mol. Biol. Rev. 71: 551-575 [Abstract] [Full Text]  
  • Satchell, K. J. F. (2007). MARTX, Multifunctional Autoprocessing Repeats-in-Toxin Toxins. Infect. Immun. 75: 5079-5084 [Full Text]  
  • Silver, A. C., Rabinowitz, N. M., Kuffer, S., Graf, J. (2007). Identification of Aeromonas veronii Genes Required for Colonization of the Medicinal Leech, Hirudo verbana. J. Bacteriol. 189: 6763-6772 [Abstract] [Full Text]  
  • Figueras, M. J., Horneman, A. J., Martinez-Murcia, A., Guarro, J. (2007). Controversial data on the association of Aeromonas with diarrhoea in a recent Hong Kong study. J Med Microbiol 56: 996-998 [Full Text]  
  • Rio, R. V. M., Anderegg, M., Graf, J. (2007). Characterization of a catalase gene from Aeromonas veronii, the digestive-tract symbiont of the medicinal leech. Microbiology 153: 1897-1906 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»