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Journal of Bacteriology, December 2006, p. 8272-8282, Vol. 188, No. 23
0021-9193/06/$08.00+0     doi:10.1128/JB.00621-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genome Sequence of Aeromonas hydrophila ATCC 7966^T: Jack of All Trades

Rekha Seshadri,^1* Sam W. Joseph,² Ashok K. Chopra,⁷ Jian Sha,⁷ Jonathan Shaw,⁵ Joerg Graf,⁶ Daniel Haft,¹ Martin Wu,¹ Qinghu Ren,¹ M. J. Rosovitz,¹ Ramana Madupu,¹ Luke Tallon,¹ Mary Kim,¹ Shaohua Jin,¹ Hue Vuong,¹ O. Colin Stine,³ Afsar Ali,³ Amy J. Horneman,^3,4,* and John F. Heidelberg^1,2,,

The Institute for Genomic Research, Division of J. Craig Venter Institute, Rockville, MD 20850,¹ Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742,² Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201,³ Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland,⁴ Division of Genomic Medicine, Section of Functional Genomics, University of Sheffield Medical School, Sheffield, S10 2RX, United Kingdom,⁵ Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269,⁶ Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555⁷

Received 2 May 2006/ Accepted 6 September 2006

The complete genome of Aeromonas hydrophila ATCC 7966^T was sequenced. Aeromonas, a ubiquitous waterborne bacterium, has been placed by the Environmental Protection Agency on the Contaminant Candidate List because of its potential to cause human disease. The 4.7-Mb genome of this emerging pathogen shows a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer upon this organism the ability to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagellum, that are reported in other A. hydrophila strains are not identified in the sequenced isolate, ATCC 7966^T. Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, and phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative as well as industrial potential. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments.

Published ahead of print on 15 September 2006.

A.J.H. and J.F.H. contributed equally to the manuscript.

Present address: Department of Biological Sciences, Philip K. Wrigley Marine Science Center, University of Southern California, Avalon, CA 90704.

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