This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mondragón, V.
Right arrow Articles by Georgellis, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mondragón, V.
Right arrow Articles by Georgellis, D.

 Previous Article  |  Next Article 

Journal of Bacteriology, December 2006, p. 8303-8306, Vol. 188, No. 23
0021-9193/06/$08.00+0     doi:10.1128/JB.01052-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

pH-Dependent Activation of the BarA-UvrY Two-Component System in Escherichia coli{triangledown}

Verónica Mondragón,1 Bernardo Franco,1 Kristina Jonas,2 Kazushi Suzuki,3 Tony Romeo,3 Öjar Melefors,2 and Dimitris Georgellis1*

Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México,1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden,2 Department of Microbiology and Immunology, Emory University School of Medicine, 3133 Rollins Research Center, 1510 Clifton Road NE, Atlanta, Georgia 303223

Received 18 July 2006/ Accepted 6 September 2006

The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively. Although this system plays a major role in the regulation of central carbon metabolism, motility, and biofilm formation by controlling the expression of the CsrB and CsrC noncoding RNAs, the environmental conditions and the physiological signal(s) to which it responds remain obscure. In this study, we explored the effect of external pH on the activity of BarA/UvrY. Our results indicate that a pH lower than 5.5 provides an environment that does not allow activation of the BarA/UvrY signaling pathway.

* Corresponding author. Mailing address: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México. Phone: (52) 55 5622 5738. Fax: (52) 55 5622 5611. E-mail: dimitris{at}ifc.unam.mx.

{triangledown} Published ahead of print on 15 September 2006.

Journal of Bacteriology, December 2006, p. 8303-8306, Vol. 188, No. 23
0021-9193/06/$08.00+0     doi:10.1128/JB.01052-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Karatan, E., Watnick, P. (2009). Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms. Microbiol. Mol. Biol. Rev. 73: 310-347 [Abstract] [Full Text]  
  • Biswas, I., Drake, L., Biswas, S. (2007). Regulation of gbpC Expression in Streptococcus mutans. J. Bacteriol. 189: 6521-6531 [Abstract] [Full Text]  
  • Baker, C. S., Eory, L. A., Yakhnin, H., Mercante, J., Romeo, T., Babitzke, P. (2007). CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence. J. Bacteriol. 189: 5472-5481 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»