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pH-Dependent Activation of the BarA-UvrY Two-Component System in Escherichia coli

Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México,¹ Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden,² Department of Microbiology and Immunology, Emory University School of Medicine, 3133 Rollins Research Center, 1510 Clifton Road NE, Atlanta, Georgia 30322³

Received 18 July 2006/ Accepted 6 September 2006

The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively. Although this system plays a major role in the regulation of central carbon metabolism, motility, and biofilm formation by controlling the expression of the CsrB and CsrC noncoding RNAs, the environmental conditions and the physiological signal(s) to which it responds remain obscure. In this study, we explored the effect of external pH on the activity of BarA/UvrY. Our results indicate that a pH lower than 5.5 provides an environment that does not allow activation of the BarA/UvrY signaling pathway.

Published ahead of print on 15 September 2006.

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