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Journal of Bacteriology, December 2006, p. 8534-8542, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.00846-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Rapid Evolution of Diminished Transformability in Acinetobacter baylyi{triangledown}

Jamie M. Bacher,1* David Metzgar,2 and Valérie de Crécy-Lagard1*

Skaggs Institute for Chemical Biology and Departments of Molecular Biology and Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., BCC-379, La Jolla, California 92037,1 Department of Defense, Center for Deployment Health Research, Naval Health Research Center, San Diego, California 92186-51222

Received 14 June 2006/ Accepted 25 September 2006

The reason for genetic exchange remains a crucial question in evolutionary biology. Acinetobacter baylyi strain ADP1 is a highly competent and recombinogenic bacterium. We compared the parallel evolution of wild-type and engineered noncompetent lineages of A. baylyi in the laboratory. If transformability were to result in an evolutionary benefit, it was expected that competent lineages would adapt more rapidly than noncompetent lineages. Instead, regardless of competency, lineages adapted to the same extent under several laboratory conditions. Furthermore, competent lineages repeatedly evolved a much lower level of transformability. The loss of competency may be due to a selective advantage or the irreversible transfer of loss-of-function alleles of genes required for transformation within the competent population.

* Corresponding author. Mailing address for Jamie M. Bacher: Skaggs Institute for Chemical Biology and Departments of Molecular Biology and Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Rd., BCC-379, La Jolla, CA 92037. Phone: (858) 784-8974. Fax: (858) 784-8990. E-mail: jbacher{at}scripps.edu. Mailing address for Valérie de Crécy-Lagard: University of Florida, Microbiology and Cell Science, Building 981, Museum Road, Gainesville, FL 32611-0700. Phone: (352) 392-9416. Fax: (352) 392-5922. E-mail: vcrecy{at}ufl.edu.

{triangledown} Published ahead of print on 6 October 2006.

Journal of Bacteriology, December 2006, p. 8534-8542, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.00846-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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