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Journal of Bacteriology, December 2006, p. 8655-8657, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01049-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Iron Starvation Triggers the Stringent Response and Induces Amino Acid Biosynthesis for Bacillibactin Production in Bacillus subtilis ^,

Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Hans-Meerwein-Str., D-35032 Marburg, Germany,¹ Molecular Genetics Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, the Netherlands²

Received 18 July 2006/ Accepted 20 September 2006

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

Published ahead of print on 29 September 2006.

Supplemental material for this article may be found at http://jb.asm.org/.

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