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Journal of Bacteriology, December 2006, p. 8655-8657, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01049-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Iron Starvation Triggers the Stringent Response and Induces Amino Acid Biosynthesis for Bacillibactin Production in Bacillus subtilis{triangledown} ,{dagger}

Marcus Miethke,1 Helga Westers,2 Evert-Jan Blom,2 Oscar P. Kuipers,2 and Mohamed A. Marahiel1*

Fachbereich Chemie/Biochemie der Philipps-Universität Marburg, Hans-Meerwein-Str., D-35032 Marburg, Germany,1 Molecular Genetics Group, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, the Netherlands2

Received 18 July 2006/ Accepted 20 September 2006

Iron deprivation in bacteria causes the derepression of genes controlled by the ferric uptake regulator (Fur). The present microarray analysis of iron-starved Bacillus subtilis cells grown in minimal medium unveils additional physiological effects on a large number of genes linked to stringent-response regulation and to genes involved in amino acid biosynthesis associated with pathways essential for bacillibactin production.

* Corresponding author. Mailing address: Philipps-Universität Marburg, FB Chemie-Biochemie, Hans-Meerwein-Str., D-35032 Marburg, Germany. Phone: 49 6421 282 5722. Fax: 49 6421 282 2191. E-mail: marahiel{at}chemie.uni-marburg.de.

{triangledown} Published ahead of print on 29 September 2006.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, December 2006, p. 8655-8657, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01049-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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