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Journal of Bacteriology, December 2006, p. 8666-8668, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Heme Biosynthesis in Methanosarcina barkeri via a Pathway Involving Two Methylation Reactions{triangledown} ,{dagger}

Bärbel Buchenau,1 Jörg Kahnt,1 Ilka U. Heinemann,2 Dieter Jahn,2 and Rudolf K. Thauer1*

Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße, D-35043 Marburg, Germany,1 Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany2

Received 24 August 2006/ Accepted 28 September 2006

The methanogenic archaeon Methanosarcina barkeri synthesizes protoheme via precorrin-2, which is formed from uroporphyrinogen III in two consecutive methylation reactions utilizing S-adenosyl-L-methionine. The existence of this pathway, previously exclusively found in the sulfate-reducing {delta}-proteobacterium Desulfovibrio vulgaris, was demonstrated for M. barkeri via the incorporation of two methyl groups from methionine into protoheme.

* Corresponding author. Mailing address: Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany. Phone: 49 6421 178 101. Fax: 49 6421 178 109. E-mail: thauer{at}mpi-marburg.mpg.de.

{triangledown} Published ahead of print on 6 October 2006.

{dagger} Dedicated to Herbert Friedmann, University of Chicago, on the occasion of his 80th birthday, 19 June 2007.

Journal of Bacteriology, December 2006, p. 8666-8668, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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