This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buchenau, B.
Right arrow Articles by Thauer, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buchenau, B.
Right arrow Articles by Thauer, R. K.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*(L)-METHIONINE

 Previous Article  |  Next Article 

Journal of Bacteriology, December 2006, p. 8666-8668, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Heme Biosynthesis in Methanosarcina barkeri via a Pathway Involving Two Methylation Reactions{triangledown} ,{dagger}

Bärbel Buchenau,1 Jörg Kahnt,1 Ilka U. Heinemann,2 Dieter Jahn,2 and Rudolf K. Thauer1*

Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Straße, D-35043 Marburg, Germany,1 Institute of Microbiology, Technical University of Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany2

Received 24 August 2006/ Accepted 28 September 2006

The methanogenic archaeon Methanosarcina barkeri synthesizes protoheme via precorrin-2, which is formed from uroporphyrinogen III in two consecutive methylation reactions utilizing S-adenosyl-L-methionine. The existence of this pathway, previously exclusively found in the sulfate-reducing {delta}-proteobacterium Desulfovibrio vulgaris, was demonstrated for M. barkeri via the incorporation of two methyl groups from methionine into protoheme.

* Corresponding author. Mailing address: Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, D-35043 Marburg, Germany. Phone: 49 6421 178 101. Fax: 49 6421 178 109. E-mail: thauer{at}mpi-marburg.mpg.de.

{triangledown} Published ahead of print on 6 October 2006.

{dagger} Dedicated to Herbert Friedmann, University of Chicago, on the occasion of his 80th birthday, 19 June 2007.

Journal of Bacteriology, December 2006, p. 8666-8668, Vol. 188, No. 24
0021-9193/06/$08.00+0     doi:10.1128/JB.01349-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»