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NnrA Is Required for Full Virulence and Regulates Several Brucella melitensis Denitrification Genes

Valérie Haine,^1, Marie Dozot,¹ Jacques Dornand,² Jean-Jacques Letesson,¹ and Xavier De Bolle^1*

Unité de Recherche en Biologie Moléculaire (URBM), University of Namur, Belgium,¹ INSERM U431, University of Montpellier II, France²

Received 11 August 2005/ Accepted 14 November 2005

We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.

Present address: Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, PA 19122.

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