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Journal of Bacteriology, February 2006, p. 1628-1632, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1628-1632.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Eukaryotic-Type Serine/Threonine Protein Kinase Is Required for Biofilm Formation, Genetic Competence, and Acid Resistance in Streptococcus mutans

Haitham Hussain,1 Pavel Branny,2 and Elaine Allan1*

Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom,1 Cell and Molecular Microbiology Division, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic2

Received 30 September 2005/ Accepted 22 November 2005

We report an operon encoding a eukaryotic-type serine/threonine protein kinase (STPK) and its cognate phosphatase (STPP) in Streptococcus mutans. Mutation of the gene encoding the STPK produced defects in biofilm formation, genetic competence, and acid resistance, determinants important in caries pathogenesis.

* Corresponding author. Mailing address: Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom. Phone: 44(0)20 7915 1256. Fax: 44(0)20 7915 1127. E-mail: e.allan{at}eastman.ucl.ac.uk.

Journal of Bacteriology, February 2006, p. 1628-1632, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1628-1632.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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