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Journal of Bacteriology, February 2006, p. 1628-1632, Vol. 188, No. 4
0021-9193/06/$08.00+0     doi:10.1128/JB.188.4.1628-1632.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

A Eukaryotic-Type Serine/Threonine Protein Kinase Is Required for Biofilm Formation, Genetic Competence, and Acid Resistance in Streptococcus mutans

Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom,¹ Cell and Molecular Microbiology Division, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic²

Received 30 September 2005/ Accepted 22 November 2005

We report an operon encoding a eukaryotic-type serine/threonine protein kinase (STPK) and its cognate phosphatase (STPP) in Streptococcus mutans. Mutation of the gene encoding the STPK produced defects in biofilm formation, genetic competence, and acid resistance, determinants important in caries pathogenesis.

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