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Journal of Bacteriology, April 2006, p. 2711-2714, Vol. 188, No. 7
0021-9193/06/$08.00+0     doi:10.1128/JB.188.7.2711-2714.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

PlyPH, a Bacteriolytic Enzyme with a Broad pH Range of Activity and Lytic Action against Bacillus anthracis

Pauline Yoong, Raymond Schuch, Daniel Nelson, and Vincent A. Fischetti*

Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021

Received 11 August 2005/ Accepted 13 January 2006

We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.

* Corresponding author. Mailing address: Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021. Phone: (212) 327-8166. Fax: (212) 327-7584. E-mail: vaf{at}rockefeller.edu.

Journal of Bacteriology, April 2006, p. 2711-2714, Vol. 188, No. 7
0021-9193/06/$08.00+0     doi:10.1128/JB.188.7.2711-2714.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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