Journal of Bacteriology, April 2006, p. 2711-2714, Vol. 188, No. 7
0021-9193/06/$08.00+0 doi:10.1128/JB.188.7.2711-2714.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
PlyPH, a Bacteriolytic Enzyme with a Broad pH Range of Activity and Lytic Action against Bacillus anthracis
Pauline Yoong,
Raymond Schuch,
Daniel Nelson, and
Vincent A. Fischetti*
Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York 10021
Received 11 August 2005/
Accepted 13 January 2006
We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.
* Corresponding author. Mailing address: Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021. Phone: (212) 327-8166. Fax: (212) 327-7584. E-mail: vaf{at}rockefeller.edu.
Journal of Bacteriology, April 2006, p. 2711-2714, Vol. 188, No. 7
0021-9193/06/$08.00+0 doi:10.1128/JB.188.7.2711-2714.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Copyright © 2006 by the American Society for Microbiology. All rights reserved.