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Journal of Bacteriology, April 2006, p. 2721-2725, Vol. 188, No. 7
0021-9193/06/$08.00+0     doi:10.1128/JB.188.7.2721-2725.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Microarray Analysis of the Osmotic Stress Response in Pseudomonas aeruginosa

Arden Aspedon,1* Kelli Palmer,2,3 and Marvin Whiteley2,3

School of Allied Health Sciences, Southwestern Oklahoma State University, Weatherford, Oklahoma 73096,1 Department of Periodontics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104,2 Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 731043

Received 23 October 2005/ Accepted 13 January 2006

Transcriptional profiling of Pseudomonas aeruginosa grown under steady-state hyperosmotic stress conditions showed an up-regulation of genes associated with osmoprotectant synthesis, putative hydrophilins, and the type III secretion system with associated cytotoxins. A large number of regulatory genes, including several two-component systems not previously known to be influenced by osmolarity, were differentially expressed by P. aeruginosa in immediate response to hyperosmotic shock.

* Corresponding author. Mailing address: School of Allied Health Sciences, Southwestern Oklahoma State University, Weatherford, OK 73096. Phone: (580) 774-3046. Fax: (580) 774-7159. E-mail: arden.aspedon{at}swosu.edu.

Journal of Bacteriology, April 2006, p. 2721-2725, Vol. 188, No. 7
0021-9193/06/$08.00+0     doi:10.1128/JB.188.7.2721-2725.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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