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Journal of Bacteriology, April 2006, p. 2730-2734, Vol. 188, No. 7
0021-9193/06/$08.00+0     doi:10.1128/JB.188.7.2730-2734.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

P_II-Regulated Arginine Synthesis Controls Accumulation of Cyanophycin in Synechocystis sp. Strain PCC 6803

Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig Universität Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany,¹ Institut für Biologie, Humboldt-Universität zu Berlin, Chausseestr. 117, D-10115 Berlin, Germany,² Abteilung Pflanzenphysiologie, Universität Rostock, Albert-Einstein-Str. 3, D-18051 Rostock, Germany³

Received 1 December 2005/ Accepted 20 January 2006

Cyanophycin (multi-L-arginyl-poly-L-aspartic acid) is a nitrogen storage polymer found in most cyanobacteria and some heterotrophic bacteria. The cyanobacterium Synechocystis sp. strain PCC 6803 accumulates cyanophycin following a transition from nitrogen-limited to nitrogen-excess conditions. Here we show that the accumulation of cyanophycin depends on the activation of the key enzyme of arginine biosynthesis, N-acetyl-L-glutamate kinase, by signal transduction protein P_II.

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