This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tzeng, L.
Right arrow Articles by Singer, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tzeng, L.
Right arrow Articles by Singer, M.

 Previous Article  |  Next Article 

Journal of Bacteriology, April 2006, p. 2774-2779, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.2774-2779.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

DNA Replication during Aggregation Phase Is Essential for Myxococcus xanthus Development

Linfong Tzeng, Terri N. Ellis,{dagger} and Mitchell Singer*

Section of Microbiology and Center for Genetics and Development, The University of California, Davis, Davis, California 95616

Received 10 November 2005/ Accepted 23 January 2006

Previous studies have demonstrated that fruiting body-derived Myxococcus xanthus myxospores contain two fully replicated copies of its genome, implying developmental control of chromosome replication and septation. In this study, we employ DNA replication inhibitors to determine if chromosome replication is essential to development and the exact time frame in which chromosome replication occurs within the developmental cycle. Our results show that DNA replication during the aggregation phase is essential for developmental progression, implying the existence of a checkpoint that monitors chromosome integrity at the end of the aggregation phase.

* Corresponding author: Mailing address: Section of Microbiology, 1 Shields Ave., University of California, Davis, Davis, CA 95616. Phone: (530) 752-9005. Fax: (530) 752-9014. E-mail: mhsinger{at}ucdavis.edu.

{dagger} Present address: National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, P.O. Box 12233, Mail Stop C2-14, Research Triangle Park, NC 27709.

Journal of Bacteriology, April 2006, p. 2774-2779, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.2774-2779.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rosario, C. J., Singer, M. (2007). The Myxococcus xanthus Developmental Program Can Be Delayed by Inhibition of DNA Replication. J. Bacteriol. 189: 8793-8800 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»