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Journal of Bacteriology, April 2006, p. 3159-3161, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3159-3161.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis{dagger}

T. Dos Vultos,1 J. Blázquez,2 J. Rauzier,1 I. Matic,3 and B. Gicquel1*

Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France,1 Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología (CSIC), Madrid, Spain,2 INSERM U570, Faculte Necker-Enfants Malades, Universite Rene Descartes, Paris, France3

Received 18 November 2005/ Accepted 27 January 2006

Mycobacterium tuberculosis and Mycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, in M. tuberculosis and M. smegmatis, and MutT4, in M. smegmatis, have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.

* Corresponding author. Mailing address: Unité de Génétique Mycobactérienne, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France. Phone: 33 (1) 40 61 88 28. Fax: 33 (1) 45 68 88 43. E-mail: bgicquel{at}pasteur.fr.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, April 2006, p. 3159-3161, Vol. 188, No. 8
0021-9193/06/$08.00+0     doi:10.1128/JB.188.8.3159-3161.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kordulakova, J., Janin, Y. L., Liav, A., Barilone, N., Dos Vultos, T., Rauzier, J., Brennan, P. J., Gicquel, B., Jackson, M. (2007). Isoxyl Activation Is Required for Bacteriostatic Activity against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51: 3824-3829 [Abstract] [Full Text]  


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