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Journal of Bacteriology, May 2006, p. 3412-3414, Vol. 188, No. 9
0021-9193/06/$08.00+0     doi:10.1128/JB.188.9.3412-3414.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Protein Splicing of SufB Is Crucial for the Functionality of the Mycobacterium tuberculosis SUF Machinery

Gaëlle Huet, Jean-Philippe Castaing, Didier Fournier, Mamadou Daffé, and Isabelle Saves*

Department of Molecular Mechanisms of Mycobacterial Infections, Institut de Pharmacologie et Biologie Structurale (UMR5089), CNRS/Université Paul Sabatier Toulouse III, 205 Route de Narbonne, F-31077 Toulouse Cedex, France

Received 29 December 2005/ Accepted 15 February 2006

The SufBCD complex is an essential component of the SUF machinery of [Fe-S] cluster biogenesis in many organisms. We show here that in Mycobacterium tuberculosis the formation of this complex is dependent on the protein splicing of SufB, suggesting that this process is a potential new target for antituberculous drugs.

* Corresponding author. Mailing address: Department of Molecular Mechanisms of Mycobacterial Infections, Institut de Pharmacologie et Biologie Structurale (UMR5089), CNRS/Université Paul Sabatier Toulouse III, 205 Route de Narbonne, F-31077 Toulouse Cedex, France. Phone: 33 561 175 470. Fax: 33 561 175 994. E-mail: Isabelle.Saves{at}ipbs.fr.

Journal of Bacteriology, May 2006, p. 3412-3414, Vol. 188, No. 9
0021-9193/06/$08.00+0     doi:10.1128/JB.188.9.3412-3414.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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