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Journal of Bacteriology, May 2006, p. 3420-3423, Vol. 188, No. 9
0021-9193/06/$08.00+0     doi:10.1128/JB.188.9.3420-3423.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of Escherichia coli Chromosomal mazEF by Stressful Conditions Causes an Irreversible Loss of Viability

Ilana Kolodkin-Gal and Hanna Engelberg-Kulka*

Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

Received 20 December 2005/ Accepted 22 February 2006

mazEF is a stress-induced toxin-antitoxin module located on the chromosomes of many bacteria. Here we induced Escherichia coli chromosomal mazEF by various stressful conditions. We found an irreversible loss of viability, which is the basic characteristic of cell death. These results further support our previous conclusion that E. coli mazEF mediation of cell death is not a passive process, but an active and genetically "programmed" death response.

* Corresponding author. Mailing address: Department of Molecular Biology, The Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel. Phone: 972-2-675-8250. Fax: 972-2-678-4010. E-mail: hanita{at}cc.huji.ac.il.

Journal of Bacteriology, May 2006, p. 3420-3423, Vol. 188, No. 9
0021-9193/06/$08.00+0     doi:10.1128/JB.188.9.3420-3423.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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