This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kolodkin-Gal, I. Articles by Engelberg-Kulka, H. Search for Related Content PubMed PubMed Citation Articles by Kolodkin-Gal, I. Articles by Engelberg-Kulka, H.

 Previous Article  |  Next Article 

Journal of Bacteriology, May 2006, p. 3420-3423, Vol. 188, No. 9
0021-9193/06/$08.00+0     doi:10.1128/JB.188.9.3420-3423.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of Escherichia coli Chromosomal mazEF by Stressful Conditions Causes an Irreversible Loss of Viability

Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

Received 20 December 2005/ Accepted 22 February 2006

mazEF is a stress-induced toxin-antitoxin module located on the chromosomes of many bacteria. Here we induced Escherichia coli chromosomal mazEF by various stressful conditions. We found an irreversible loss of viability, which is the basic characteristic of cell death. These results further support our previous conclusion that E. coli mazEF mediation of cell death is not a passive process, but an active and genetically "programmed" death response.

This article has been cited by other articles:

• Saavedra De Bast, M., Mine, N., Van Melderen, L. (2008). Chromosomal Toxin-Antitoxin Systems May Act as Antiaddiction Modules. J. Bacteriol. 190: 4603-4609 [Abstract] [Full Text]  
• Lee, S., Kim, M. H., Kang, B. S., Kim, J.-S., Kim, G.-H., Kim, Y.-G., Kim, K. J. (2008). Crystal Structure of Escherichia coli MazG, the Regulator of Nutritional Stress Response. J. Biol. Chem. 283: 15232-15240 [Abstract] [Full Text]  
• Kolodkin-Gal, I., Engelberg-Kulka, H. (2008). The Extracellular Death Factor: Physiological and Genetic Factors Influencing Its Production and Response in Escherichia coli. J. Bacteriol. 190: 3169-3175 [Abstract] [Full Text]  
• Rice, K. C., Bayles, K. W. (2008). Molecular Control of Bacterial Death and Lysis. Microbiol. Mol. Biol. Rev. 72: 85-109 [Abstract] [Full Text]  
• Drlica, K., Malik, M., Kerns, R. J., Zhao, X. (2008). Quinolone-Mediated Bacterial Death. Antimicrob. Agents Chemother. 52: 385-392 [Full Text]  
• Kolodkin-Gal, I., Hazan, R., Gaathon, A., Carmeli, S., Engelberg-Kulka, H. (2007). A Linear Pentapeptide Is a Quorum-Sensing Factor Required for mazEF-Mediated Cell Death in Escherichia coli. Science 318: 652-655 [Abstract] [Full Text]  
• Tsilibaris, V., Maenhaut-Michel, G., Mine, N., Van Melderen, L. (2007). What Is the Benefit to Escherichia coli of Having Multiple Toxin-Antitoxin Systems in Its Genome?. J. Bacteriol. 189: 6101-6108 [Abstract] [Full Text]  
• Magnuson, R. D. (2007). Hypothetical Functions of Toxin-Antitoxin Systems. J. Bacteriol. 189: 6089-6092 [Full Text]  
• Daines, D. A., Wu, M. H., Yuan, S. Y. (2007). VapC-1 of Nontypeable Haemophilus influenzae Is a Ribonuclease. J. Bacteriol. 189: 5041-5048 [Abstract] [Full Text]  
• Button, J. E., Silhavy, T. J., Ruiz, N. (2007). A Suppressor of Cell Death Caused by the Loss of {sigma}E Downregulates Extracytoplasmic Stress Responses and Outer Membrane Vesicle Production in Escherichia coli. J. Bacteriol. 189: 1523-1530 [Abstract] [Full Text]  
• Budde, P. P., Davis, B. M., Yuan, J., Waldor, M. K. (2007). Characterization of a higBA Toxin-Antitoxin Locus in Vibrio cholerae. J. Bacteriol. 189: 491-500 [Abstract] [Full Text]  
• Moritz, E. M., Hergenrother, P. J. (2007). Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proc. Natl. Acad. Sci. USA 104: 311-316 [Abstract] [Full Text]