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Molecular Evolution of the H-NS Protein: Interaction with Hha-Like Proteins Is Restricted to Enterobacteriaceae

Department of Microbiology, University of Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain,¹ Laboratory of Biomolecular NMR, Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain²

Received 27 July 2006/ Accepted 25 September 2006

We show here that chromosomal hha-like genes are restricted to the Enterobacteriaceae. The H-NS N-terminal domain of members of this family includes an unaltered seven-amino-acid sequence located between helixes 1 and 2, termed the Hha signature, that contains key residues for H-NS-Hha interaction.

Published ahead of print on 13 October 2006.

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