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Journal of Bacteriology, January 2007, p. 280-283, Vol. 189, No. 1
0021-9193/07/$08.00+0     doi:10.1128/JB.01221-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Influence of Wall Teichoic Acid on Lysozyme Resistance in Staphylococcus aureus{triangledown}

Agnieszka Bera,1,{dagger} Raja Biswas,1,{dagger} Silvia Herbert,1 Emir Kulauzovic,2 Christopher Weidenmaier,2 Andreas Peschel,2 and Friedrich Götz1*

Microbial Genetics, University of Tübingen, 72076 Tübingen, Germany,1 Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, 72076 Tübingen, Germany2

Received 4 August 2006/ Accepted 20 October 2006

Staphylococcus aureus peptidoglycan (PG) is completely resistant to the hydrolytic activity of lysozyme. Here we show that modifications in PG by O acetylation, wall teichoic acid, and a high degree of cross-linking contribute to this resistance.


* Corresponding author. Mailing address: Mikrobielle Genetik, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. Phone: 0049 7071 2974636. Fax: 0049 7071 295039. E-mail: friedrich.goetz{at}uni-tuebingen.de.

{triangledown} Published ahead of print on 3 November 2006.

{dagger} Both authors contributed equally to this work.


Journal of Bacteriology, January 2007, p. 280-283, Vol. 189, No. 1
0021-9193/07/$08.00+0     doi:10.1128/JB.01221-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.




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