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Journal of Bacteriology, June 2007, p. 4161-4167, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00106-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genome Sequence and Analysis of a Propionibacterium acnes Bacteriophage{triangledown} ,{dagger}

Mark D. Farrar,1* Karen M. Howson,1 Richard A. Bojar,1 David West,2 James C. Towler,1 James Parry,1 Katharine Pelton,1 and Keith T. Holland1

Skin Research Centre, Institute of Molecular & Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom,1 Sarum Biosciences Ltd., 8 Centre One, Lysander Way, Old Sarum Park, Salisbury SP4 6BU, United Kingdom2

Received 19 January 2007/ Accepted 22 March 2007

Cutaneous propionibacteria are important commensals of human skin and are implicated in a wide range of opportunistic infections. Propionibacterium acnes is also associated with inflammatory acne vulgaris. Bacteriophage PA6 is the first phage of P. acnes to be sequenced and demonstrates a high degree of similarity to many mycobacteriophages both morphologically and genetically. PA6 possesses an icosahedreal head and long noncontractile tail characteristic of the Siphoviridae. The overall genome organization of PA6 resembled that of the temperate mycobacteriophages, although the genome was much smaller, 29,739 bp (48 predicted genes), compared to, for example, 50,550 bp (86 predicted genes) for the Bxb1 genome. PA6 infected only P. acnes and produced clear plaques with turbid centers, but it lacked any obvious genes for lysogeny. The host range of PA6 was restricted to P. acnes, but the phage was able to infect and lyse all P. acnes isolates tested. Sequencing of the PA6 genome makes an important contribution to the study of phage evolution and propionibacterial genetics.

* Corresponding author. Mailing address: Skin Research Centre, Institute of Molecular & Cellular Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 1133435616. Fax: 44 1133435638. E-mail: M.D.Farrar{at}leeds.ac.uk

{triangledown} Published ahead of print on 30 March 2007.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, June 2007, p. 4161-4167, Vol. 189, No. 11
0021-9193/07/$08.00+0     doi:10.1128/JB.00106-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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