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Journal of Bacteriology, July 2007, p. 4953-4956, Vol. 189, No. 13
0021-9193/07/$08.00+0     doi:10.1128/JB.00109-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Structure-Based Functional Analysis of the Replication Protein of Plasmid R6K: Key Amino Acids at the {pi}/DNA Interface{triangledown}

Selvi Kunnimalaiyaan, Sheryl A. Rakowski, and Marcin Filutowicz*

Department of Bacteriology, University of Wisconsin, 420 Henry Mall, Madison, Wisconsin 53706

Received 19 January 2007/ Accepted 13 April 2007

In previous work, we characterized the bases in an iteron of plasmid R6K that are important for the binding of {pi} protein monomers and dimers. Here we investigate the following six amino acids of {pi}, encoded by pir, hypothesized to be important for DNA contact: Ser71, Try74, Gly131, Gly211, Arg225, and Arg254.

* Corresponding author. Mailing address: Department of Bacteriology, University of Wisconsin, 420 Henry Mall, Madison, WI 53706. Phone: (608) 262-6947. Fax: (608) 262-9865. E-mail: msfiluto{at}facstaff.wisc.edu

{triangledown} Published ahead of print on 20 April 2007.

Journal of Bacteriology, July 2007, p. 4953-4956, Vol. 189, No. 13
0021-9193/07/$08.00+0     doi:10.1128/JB.00109-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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