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Journal of Bacteriology, July 2007, p. 5393-5398, Vol. 189, No. 14
0021-9193/07/$08.00+0     doi:10.1128/JB.00228-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Requirement for YaeT in the Outer Membrane Assembly of Autotransporter Proteins{triangledown}

Sumita Jain{dagger} and Marcia B. Goldberg*

Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Cambridge, Massachusetts

Received 11 February 2007/ Accepted 7 May 2007

Autotransporters constitute the largest group of secreted proteins in gram-negative bacteria. Autotransporter secretion involves the insertion of a carboxy-terminal beta barrel into and the translocation of an amino-terminal domain across the outer membrane. Here, we demonstrate that secretion of autotransporters from several organisms requires the outer membrane assembly factor YaeT.

* Corresponding author. Mailing address: Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139. Phone: (617) 768-8740. Fax: (617) 768-8738. E-mail: mgoldberg1{at}partners.org

{triangledown} Published ahead of print on 18 May 2007.

{dagger} Present address: Department of Periodontics, University of Washington, Seattle, WA 98195.

Journal of Bacteriology, July 2007, p. 5393-5398, Vol. 189, No. 14
0021-9193/07/$08.00+0     doi:10.1128/JB.00228-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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