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Two ABC Transporter Operons and the Antimicrobial Resistance Gene mtrF Are pilT Responsive in Neisseria gonorrhoeae

Alexandra Friedrich,^1* Cindy G. Arvidson,² William M. Shafer,^3,4 Eun-Hee Lee,³ and Magdalene So^1,

Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, Portland, Oregon 97201-3098,¹ Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824,² Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322,³ Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, Georgia 30033⁴

Received 28 February 2007/ Accepted 7 May 2007

Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.

Published ahead of print on 11 May 2007.

Present address: University of Arizona, Tucson, AZ 85719.

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