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folA, a New Member of the TyrR Regulon in Escherichia coli K-12

Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia,¹ Department of Frontier Bioscience and Micro-Nano Technology Research Center, Hosei University, Koganei, Tokyo 184-8584, Japan²

Received 29 March 2007/ Accepted 29 May 2007

The folA gene was identified as a new member of the TyrR regulon by genomic SELEX. Binding of TyrR to two sites in folA activated its transcription. Mutations in the N-terminal or central domain of TyrR, the subunit of RNA polymerase, or integration host factor all abolished activation of the folA promoter.

Published ahead of print on 8 June 2007.