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Genetic Structure of the nadA and nadB Antivirulence Loci in Shigella spp.

Anne-Laure Prunier, Raymond Schuch, Reinaldo E. Fernández, and Anthony T. Maurelli^*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799

Received 5 April 2007/ Accepted 18 June 2007

Comparison of nadA and nadB in 14 Shigella strains and enteroinvasive Escherichia coli versus E. coli showed that at least one locus is altered in all strains. These observations explain the characteristic nicotinic acid auxotrophy of Shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.

Published ahead of print on 22 June 2007.

Present address: Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021.

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