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Journal of Bacteriology, September 2007, p. 6490-6493, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00594-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

EbpR Is Important for Biofilm Formation by Activating Expression of the Endocarditis and Biofilm-Associated Pilus Operon (ebpABC) of Enterococcus faecalis OG1RF{triangledown}

Agathe Bourgogne,1,2 Kavindra V. Singh,1,2 Kristina A. Fox,3 Kathryn J. Pflughoeft,3 Barbara E. Murray,1,2,3* and Danielle A. Garsin2,3

Division of Infectious Diseases, Department of Medicine,1 Center for the Study of Emerging and Re-emerging Pathogens,2 Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 770303

Received 17 April 2007/ Accepted 14 June 2007

We identify ef1090 (renamed ebpR) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC. An ebpR deletion ({Delta}ebpR) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation.

* Corresponding author. Mailing address: Division of Infectious Diseases, Center for the Study of Emerging and Re-emerging Pathogens, MSB 2.112, University of Texas Medical School, 6431 Fannin St., Houston, TX 77030. Phone: (713) 500-6745. Fax: (713) 500-6766. E-mail: BEM.asst{at}uth.tmc.edu

{triangledown} Published ahead of print on 22 June 2007.

Journal of Bacteriology, September 2007, p. 6490-6493, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00594-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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