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Journal of Bacteriology, September 2007, p. 6494-6496, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00622-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genetic Code Ambiguity Confers a Selective Advantage on Acinetobacter baylyi{triangledown}

Jamie M. Bacher,1,{dagger} William F. Waas,1 David Metzgar,1,{ddagger} Valérie de Crécy-Lagard,2 and Paul Schimmel1*

The Scripps Research Institute, 10550 N. Torrey Pines Rd., BCC-379, La Jolla, California 92037,1 University of Florida, Microbiology and Cell Science, Building 981, Museum Road, Gainesville, Florida 32611-07002

Received 23 April 2007/ Accepted 26 June 2007

A primitive genetic code, composed of a smaller set of amino acids, may have expanded via recursive periods of genetic code ambiguity that were followed by specificity. Here we model a step in this process by showing how genetic code ambiguity could result in an enhanced growth rate in Acinetobacter baylyi.

* Corresponding author. Mailing address: The Scripps Research Institute, 10550 N. Torrey Pines Rd., BCC-379, La Jolla, CA 92037. Phone: (858) 784-8972. Fax: (858) 784-8990. E-mail: schimmel{at}scripps.edu

{triangledown} Published ahead of print on 6 July 2007.

{dagger} Present address: Rincon Pharmaceuticals, Inc., 3030 Bunker Hill St., Ste. 318, San Diego, CA 92109.

{ddagger} Present address: Department of Defense, Center for Deployment Health Research, Naval Health Research Center, San Diego, CA 92186-5122.

Journal of Bacteriology, September 2007, p. 6494-6496, Vol. 189, No. 17
0021-9193/07/$08.00+0     doi:10.1128/JB.00622-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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