This Article Full Text Full Text (PDF) Supplemental material Other Versions of this Article: JB.01437-06v1 189/2/650    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Loughman, J. A. Articles by Caparon, M. G. Search for Related Content PubMed PubMed Citation Articles by Loughman, J. A. Articles by Caparon, M. G.

Contribution of Invariant Residues to the Function of Rgg Family Transcription Regulators ^,

Jennifer A. Loughman and Michael G. Caparon^*

Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110

Received 11 September 2006/ Accepted 30 October 2006

The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.

Published ahead of print on 10 November 2006.

Supplemental material for this article may be found at http://jb.asm.org/.

Present address: Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., Box 8208, Saint Louis, MO 63110-1093.

This article has been cited by other articles:

• Ibrahim, M., Guillot, A., Wessner, F., Algaron, F., Besset, C., Courtin, P., Gardan, R., Monnet, V. (2007). Control of the Transcription of a Short Gene Encoding a Cyclic Peptide in Streptococcus thermophilus: a New Quorum-Sensing System?. J. Bacteriol. 189: 8844-8854 [Abstract] [Full Text]